Cyclin D1 immunohistochemical staining to separate benign from malignant mesothelial proliferations
نویسندگان
چکیده
منابع مشابه
Proliferative Marker in Distinction between Benign and Malignant Mesothelial Proliferations
Background: Differentiation of benign from malignant mesothelial proliferations is a major problem in the pathology of the serosal membranes, particularly in small biopsy specimen. This study was conducted for the evaluation of proliferative marker for distinction between malignant mesothelioma (MM) and mesothelial hyperplasia (MH). Materials and Methods: Thirty six cases of malignant mesotheli...
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Distinguishing malignant mesotheliomas from benign mesothelial proliferations on hematoxylin and eosin-stained sections can be extremely challenging. Various immunohistochemical stains have been suggested to help in making this distinction, but all are controversial. Recently, IMP3 (insulin-like growth factor II mRNA binding protein 3) and GLUT-1 (glucose transporter protein 1) have been propos...
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PURPOSE Prostatic carcinoma is a common and growing public health problem. Histological evaluation is fairly adequate for assessing tumor differentiation, but tumor proliferative activity is difficult to measure. Increasing evidence suggests that the factors controlling cell cycle progression also modulate the rate of ribosome biogenesis. Despite the influence of cyclin D1 and argyrophilic nucl...
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Immunohistochemical staining with a monoclonal antibody against human cyclin D1 can be used to identify breast cancers that have an amplification of the q13 region of chromosome 11. In general, the intensity of staining is directly proportional to the degree of DNA amplification. In two unusual tumors, in which the CCND1 locus is highly amplified but staining is relatively weak, it appears that...
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Hemangiomas constitute a heterogeneous group of benign vascular proliferations. Their pathogenesis is not completely understood. In this study the expression of GLUT-1, VEGF, Ki-67, bcl-2 and apoptotic index in twenty-six cases of infantile capillary hemangioma (ICH), fifteen of lobular capillary hemangioma (LCH) and nine of epithelioid hemangioma were examined. The expression of GLUT-1 was con...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2019
ISSN: 0893-3952,1530-0285
DOI: 10.1038/s41379-019-0411-9